Description

AICAR (5‑Aminoimidazole‑4‑carboxamide Ribonucleotide; ZMP)

• AICAR is a cell‑permeable metabolic intermediate and AMP‑mimetic that activates AMP‑activated protein kinase (AMPK), a key cellular energy sensor.
• Widely used as a research tool to study cellular energy metabolism, AMPK signaling, mitochondrial biogenesis, and exercise‑mimetic effects.

Key benefits (research findings)

• Activates AMPK, promoting increased glucose uptake, fatty‑acid oxidation, and mitochondrial biogenesis in cells and animal models.
• Shifts cellular metabolism toward catabolic, energy‑producing pathways, which can improve endurance and metabolic parameters in preclinical studies.
• Useful for probing mechanisms of metabolic disease, insulin sensitivity, exercise physiology, and mitochondrial function.

Primary uses

• Preclinical and translational research into metabolic disorders (diabetes, obesity), exercise physiology, AMPK biology, and mitochondrial adaptations.
• Cellular and animal model experiments examining signaling, gene expression, and metabolic flux under AMPK activation.
• Mechanistic studies for drug discovery targeting energy‑sensing pathways.

Who it’s for

• Qualified researchers and laboratories conducting regulated in vitro or in vivo studies with institutional approvals.
• Not intended for human self‑administration or clinical treatment outside approved clinical trials.

Suggested use (research context)

• Use only per validated protocols, supplier instructions, and institutional biosafety/ethics approvals. Dose, route, and timing depend on model system and experimental aims.
• Include appropriate controls and dose‑response/pilot studies to establish effective concentrations while monitoring metabolic endpoints.
• Avoid extrapolating animal/ cell findings to human therapeutic use without rigorous clinical testing.

Safety and storage

• Investigational research chemical; human safety and long‑term effects are not established. Do not use in humans outside authorized clinical studies.
• Potential risks: off‑target metabolic disturbances, hypoglycemia, cardiovascular effects, and unknown chronic toxicities; handle with caution.
• Follow MSDS guidance: use PPE, work in appropriate containment, avoid inhalation/ingestion/skin contact, and dispose of waste per institutional protocols.
• Storage: store lyophilized or solid AICAR per supplier recommendations (typically refrigerated or frozen in desiccated conditions). Prepare fresh working solutions as directed, aliquot to avoid repeated freeze–thaw cycles, and protect from moisture and light.

Quick facts

• Mechanism: AMP‑mimetic → activates AMPK (ZMP acts as AMP surrogate).
• Status: research tool/experimental compound; not approved as a therapeutic. AICAR usage is banned in sports by WADA (performance‑enhancing concerns).
• Procurement: available to research institutions from chemical suppliers with appropriate approvals and documentation.

Research Use Only Disclaimer

Products sold by SoCo Peptides are intended strictly for laboratory research purposes only.

These compounds are not intended for human consumption, veterinary use, household use, cosmetic use, or therapeutic application. They are not drugs, foods, or dietary supplements and have not been evaluated or approved by the FDA.

By purchasing from this website, the customer represents that they are a qualified researcher or laboratory professional and understand the risks associated with handling research materials.

All products must be handled by trained professionals in appropriate research facilities and in accordance with all applicable laws and regulations.

SoCo Peptides makes no guarantees or claims regarding safety, effectiveness, or medical benefit.