Description

MOTS‑c (Mitochondrial Open Reading Frame of the 12S rRNA — MOTS-c)

Description

• MOTS‑c is a mitochondrial‑derived peptide (16 amino acids) that acts as a metabolic regulator linking mitochondrial function to cellular and systemic metabolism.
• Investigational peptide studied for effects on insulin sensitivity, energy homeostasis, metabolic health, and exercise performance.

Key benefits (research findings)

• Enhances insulin sensitivity and improves glucose metabolism in preclinical models.
• Promotes metabolic flexibility and increases cellular energy utilization and fatty‑acid oxidation.
• May reduce diet‑induced weight gain and adiposity in animal studies.
• Exhibits cellular stress‑response signaling that can support mitochondrial function and resilience.

Primary uses

• Preclinical and translational research exploring metabolic disease (obesity, diabetes), aging, exercise physiology, and mitochondrial biology.
• Mechanistic studies probing mitochondrial‑nuclear communication and peptide‑mediated metabolic regulation.

Suggested use

• Use only according to institutional protocols, supplier recommendations, and regulatory approvals for experimental concentrations and dosing regimens.
• Typical research administration routes include intraperitoneal, subcutaneous, or other parenteral routes in animal studies; formulation and dose must be validated in pilot experiments.
• Adhere to aseptic technique, appropriate controls, and ethical approvals for animal work.

Safety and storage

• Investigational research compound — human safety profile is not established. Avoid human exposure unless within approved clinical trials.
• Handle as a laboratory chemical/biological reagent: use PPE, avoid inhalation/ingestion/skin contact, and follow MSDS guidance.
• Store lyophilized peptide per supplier instructions (commonly frozen or refrigerated in desiccated conditions); reconstitute and aliquot to minimize freeze–thaw cycles and follow stability data.

Quick facts

• Origin: encoded within the mitochondrial 12S rRNA region; part of a class of mitochondrial‑derived peptides with signaling roles.
• Mechanism: modulates metabolic pathways and stress responses, cross‑talks with nuclear signaling to influence systemic metabolism.
• Status: preclinical/translational; not approved for therapeutic use in humans.
• Procurement: available to research labs from peptide suppliers with appropriate institutional approvals.

Research Use Only Disclaimer

Products sold by SoCo Peptides are intended strictly for laboratory research purposes only.

These compounds are not intended for human consumption, veterinary use, household use, cosmetic use, or therapeutic application. They are not drugs, foods, or dietary supplements and have not been evaluated or approved by the FDA.

By purchasing from this website, the customer represents that they are a qualified researcher or laboratory professional and understand the risks associated with handling research materials.

All products must be handled by trained professionals in appropriate research facilities and in accordance with all applicable laws and regulations.

SoCo Peptides makes no guarantees or claims regarding safety, effectiveness, or medical benefit.