5-Amino-1-methylquinolinium (5-Amino-1MQ)

Description

• 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) used in preclinical research to modulate cellular methylation and NAD+ metabolism.
• Investigational research compound studied for effects on metabolism, energy homeostasis, and fibrotic or metabolic disease models.

Key benefits (research findings)

• Inhibits NNMT activity, which can alter cellular methylation capacity and conserve NAD+ precursors in experimental systems.
• Has been shown in animal and cellular models to improve metabolic parameters (e.g., insulin sensitivity, energy expenditure) and reduce adiposity in some studies.
• Demonstrates potential to modulate fibrosis and tissue remodeling in preclinical models via metabolic and epigenetic pathways.
• Useful as a tool compound to study NNMT biology, methylation balance, and NAD+-related metabolic pathways.

Primary uses

• Basic and translational research to investigate NNMT function and downstream metabolic/epigenetic effects.
• Preclinical evaluation in cell culture and animal models for metabolic disease, obesity, fibrosis, or age-related research.
• Mechanistic studies exploring interactions between methyltransferase activity, SAM/SAH balance, and NAD+ metabolism.

Suggested use

• Use only according to institutional biosafety, ethical, and regulatory approvals. Prepare and dose per validated protocols and supplier specifications for in vitro or in vivo studies.
• Handle with appropriate laboratory controls (personal protective equipment, fume hood) and use appropriate vehicle and concentration ranges determined in preliminary experiments.
• Dispose of waste and leftovers per institutional hazardous-waste procedures.

Safety and storage

• Investigational research chemical — safety profile in humans is not established. Avoid human exposure.
• Potential hazards: treat as chemical hazard; avoid inhalation, ingestion, and skin/eye contact. Follow material safety data sheet (MSDS) guidance.
• Store as recommended by supplier (typically in a cool, dry place, often refrigerated or frozen in aliquots for long-term storage) and protect from light and moisture.

Quick facts

• Mechanism: selective NNMT inhibition (investigational).
• Status: preclinical/research compound; not approved for therapeutic use in humans.
• Procurement: available from chemical suppliers for laboratory research with appropriate institutional approvals.

Research Use Only Disclaimer

Products sold by SoCo Peptides are intended strictly for laboratory research purposes only.

These compounds are not intended for human consumption, veterinary use, household use, cosmetic use, or therapeutic application. They are not drugs, foods, or dietary supplements and have not been evaluated or approved by the FDA.

By purchasing from this website, the customer represents that they are a qualified researcher or laboratory professional and understand the risks associated with handling research materials.

All products must be handled by trained professionals in appropriate research facilities and in accordance with all applicable laws and regulations.

SoCo Peptides makes no guarantees or claims regarding safety, effectiveness, or medical benefit.